Diabetes drug injected once a week gets FDA approval:: Bydureon (long-acting exenatide)

From The NYTimes:


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The FDA has twice refused to approve the long-acting exenatide (: Bydureon) in 2010, with its most serious concern is that the drug could contribute to abnormal heart rhythm. There are security issues involving pancreatitis and thyroid cancer.
: BYDUREON is a longer-lasting version of Amylin's Byetta drug exists, which is injected twice a day. Another company, alkermes, has provided technology that releases slowly: Bydureon inside the body.
Byetta and Victoza: BYDUREON, are drugs called receptor agonists GLP-1, which mimic the effect of peptides glucagonlike-1, a hormone that increases the production of insulin when blood sugar is high.

Action Figure: DPP-4 inhibitors. Note that DPP-4 inactivates GLP-1 normally. DPP-4 inhibitors that block DPP-4, which in turn leaves GLP-1. Click to enlarge the picture. I did figure with Gliffy in 2006. Inhibitors of DPP-4 action diagram is widely used in many articles on Wikipedia, with my permission.

The main ingredient is Byetta exenatide: Bydureon, which is a hormone derived from the saliva to the Gila monster, a venomous lizard found in the southwest of the United States and Mexico.
Wholesale price: Bydureon would $323 for 4 doses, or about $ 4,200 a year. That is one of the approximately 3,400 for low dose of Victoza and $ 5,000 for the high dose.
References:
Diabetes drug injected weekly Wins FDA approval. NYTimes.
Comment by Twitter:
Vaughn Eyvazian @ Vaughnsays: increased compliance with pt!
Reinaldo b. @ basanezrx: but no one stays in the minimum dose of Victoza in my experience, and that is why most companies pay for ins Byetta instead. A shame the

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